Lynparza 150 Mg 112 Film Coated Tab
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Product Description:
- Lynparza contains the active substance olaparib.
- Olaparib is a cancer medicine called a PARP (poly [adenosine diphosphate-ribose] polymerase inhibitor).
- PARP inhibitors can destroy cancer cells that are poor at repairing DNA damage.
These specific cancer cells can be identified by:
- Response to chemotherapy (cytotoxin) containing platinum, or
- To look for faulty dna repair genes, such as brca (a breast cancer gene)
What Lynparza is used for:
Lynparza is used to treat:
- A type of ovarian cancer ( BRCA -mutated) that has responded to the first standard treatment with platinum-containing chemotherapy.
- A test is used to find out if you have BRCA -mutated ovarian cancer.
Ovarian cancer that has come back:
- It is used when previous standard treatment with chemotherapy containing platinum has worked on the cancer .
- A type of ovarian cancer (HRD-positive defined by a BRCA mutation or genomic instability) that has responded to the first standard treatment with chemotherapy containing platinum and bevacizumab.
- Lynparza is used together with bevacizumab.
- A type of breast cancer (BRCA-mutated, HER2-negative) where the cancer has not spread to other parts of the body and where treatment will be given after surgery (treatment after surgery is called adjuvant treatment).
- You should have received chemotherapy before or after the operation.
- If the cancer is hormone receptor-positive, the doctor may also prescribe hormone therapy.
- A test is used to find out if you have BRCA-mutated breast cancer .
A type of breast cancer ( BRCA -mutated HER2-negative) that has spread from the original tumor:
- You should have received chemotherapy either before or after the cancer has spread.
- A test is used to find out if you have BRCA- mutated breast cancer .
- A type of pancreatic cancer ( BRCA -mutated) that has responded to the first standard treatment with platinum-containing chemotherapy.
- A test is used to find out if you have BRCA -mutated pancreatic cancer.
- A type of prostate cancer (BRCA-mutated) that has spread beyond the original tumor and no longer responds to medical or surgical treatment to reduce testosterone levels.
- You should have received certain hormonal treatments, such as enzalutamide or abiraterone acetate.
- A test is used to find out if you have BRCA-mutated prostate cancer.
- When Lynparza is given in combination with other cancer medicines, it is important that you also read the package insert for the other medicines.
- Talk to your doctor if you have any questions about these medicines.
How To Use:
- Always use this medicine exactly as your doctor, pharmacist or nurse has told you.
- Contact a doctor, pharmacist or nurse if you are unsure.
How to take this medicine:
- Swallow Lynparza tablets whole, with or without food
- Take Lynparza once in the morning and once in the evening
- Do not chew, crush, dissolve or split the tablets. This can affect how quickly the medicine enters your body
How much to take:
- Your doctor will tell you how many tablets of Lynparza to take. It is important that you take the full recommended dose every day.
- Continue to do so as long as your doctor, pharmacist or nurse has told you
- The usual recommended dose is 300 mg (2 tablets of 150 mg) twice a day - a total of 4 tablets each day
Your doctor may prescribe a different dose if:
- You have kidney problems. You will be asked to take 200 mg (2 tablets of 100 mg) twice a day – a total of 4 tablets each day
- You are taking certain medicines that may affect Lynparza.
- You get certain side effects while using Lynparza.
- Your doctor may lower the dose or stop the treatment, either for a short period or permanently
- If you take too much Lynparza:
- Contact a doctor or the nearest hospital immediately if you take more Lynparza than your usual dose.
If you have forgotten to take Lynparza:
- If you forget to take Lynparza, take your next regular dose at the scheduled time.
- You should not take a double dose (two doses at the same time) to replace a missed dose.
- Ask your doctor, pharmacist or nurse if you have any questions about the use of this medicine.
Warnings And Precautions:
Do not use Lynparza:
- If you are allergic to olaparib or any of the other ingredients of this medicine.
- If you are breastfeeding (see below for more information).
- Do not use Lynparza if any of the above applies to you.
- Talk to your doctor, pharmacist or nurse before taking Lynparza if you are unsure.
Talk to your doctor, pharmacist or nurse before or during treatment with Lynparza:
- If you have a low number of blood cells during tests.
- This can be a low number of red or white blood cells or a low number of platelets
- For more information about these side effects, including signs and symptoms to look out for (eg fever or infection , bruising or bleeding).
- In rare cases, this may be a sign of more serious problems with the bone marrow, such as 'myelodysplastic syndrome' (mds) or ' acute myelogenous leukemia ' (aml).
- If you experience any new or worsening symptoms such as difficulty breathing, coughing or heavy breathing.
- A small number of patients treated with lynparza reported inflammation of the lungs ( pneumonitis ).
- Pneumonitis is a serious condition that can often require hospital treatment.
- Talk to your doctor, pharmacist or nurse, before or during treatment with Lynparza, if you think that any of this applies to you.
Try and check:
- Your doctor will check your blood before and during treatment with Lynparza.
- You will give a blood sample.
Before treatment:
- Every month during the first year of treatment
- At regular intervals according to the doctor's decision after the first year of treatment.
- If your blood cell count drops to a low level, you may need a blood transfusion (where you get new blood or a blood-based product from a donor).
Taking Lynparza together with drink:
- Avoid drinking grapefruit juice while being treated with Lynparza. It can affect the effect of the medicine.
Contraception, pregnancy and breastfeeding:
Female patients:
- You should not use Lynparza if you are pregnant or may become pregnant.
- This is because it can harm the unborn child.
- You should not become pregnant while taking this medicine.
- If you have intercourse, you should use two safe methods of contraception while taking this medicine, and for 6 months after taking the last dose of Lynparza.
- It is not known whether Lynparza affects the effectiveness of certain hormonal contraceptives.
- Talk to your doctor if you are taking a hormonal contraceptive, as your doctor may recommend that you use a non-hormonal contraceptive in addition.
- You should take a pregnancy test before starting Lynparza, regularly during treatment, and
6 months after taking the last dose of Lynparza. - If you become pregnant during this time, you must talk to your doctor immediately.
It is not known whether Lynparza is excreted in breast milk. - You should not breast-feed if you take Lynparza and for 1 month after taking the last dose of Lynparza.
- Talk to your doctor if you plan to breastfeed.
Male patients:
- You must use a condom during sexual activity with a female partner, even if she is pregnant, while receiving Lynparza and for 3 months after the last dose.
- It is not known whether Lynparza passes into the semen.
- Your female partner must also use suitable contraception.
- You should not donate sperm when you receive Lynparza and for 3 months after the last dose.
Driving and using machines:
Lynparza can affect the ability to drive and use machines.
- Do not drive or use tools or machines if you feel dizzy, weak or tired while taking Lynparza.
Information on other ingredients in this medicine:
- This medicinal product contains less than 1 mmol sodium (23 mg) per 100 mg or 150 mg tablet, and is virtually 'sodium-free'.
Ingredints:
The active substance is olaparib.
- Each Lynparza 150 mg film-coated tablet contains 150 mg olaparib.
What Lynparza looks like and contents of the pack:
- Lynparza 150 mg tablets are green to grey-green, oval, biconvex tablets, debossed with "OP150" on one side and plain on the other.