Arena Plus 300/12.5 mg 30 Tablet

Irbesartan/Hydrochlorothiazide 300/12.5 mg

What Irbesartan/Hydrochlorothiazide is used for:

• It is a combination of Irbesartan, an angiotensin II receptor antagonist, and Hydrochlorothiazide, a thiazide diuretic, indicated for hypertension:


• In patients not adequately controlled with monotherapy.


• As initial therapy in patients likely to need multiple drugs to achieve their blood pressure goal.

Do not take Irbesartan/Hydrochlorothiazide if:

• Hypersensitivity to Irbesartan or hydrochlorothiazide 


• Hypersensitivity to sulfonamide-derived drugs (like sulfamethoxazole/trimethoprim, sulfasalazine)


• Anuria present (not enough urine production)


• Renal impairment


• Liver impairment

Warnings & Precautions:

• Talk to your doctor or pharmacist before taking Irbesartan/Hydrochlorothiazide


• To monitor kidney functions 


• To monitor potassium levels 


• If you have vision problems like myopia or glaucoma


• If you have lupus 


• If you are at risk to be volume depleted (dehydrated)

Possible Side Effects: 

• Fatigue 


• Dizziness


• Muscle pain

Other medicines and Irbesartan/hydrochlorothiazide:

• Tell your doctor or pharmacist about all medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.


• Increased risk of kidney damage and reduction of its effects when taken with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and COX-2 inhibitors (like ibuprofen, ketoprfen, celecoxib)


• Increased risk of lithium toxicity when taken together


• Not recommended use with potassium supplements to avoid increase of potassium levels in blood.

With only Hydrochlorothiazide:

• Avoid cholestyramine and colestipol to have maximum absorption


• Adjust dose of antidiabetics 


• Monitor while using alcohol, barbiturates and narcotics because of the potential hypotension

How to take Irbesartan/hydrochlorothiazide:

• Adults above 18 years of age and CrCl >30ml/min: 


• The usual dose is: 1 tablet daily 


• Irbesartan//hydrochlorothiazide tablet can be taken with or without food 


• It may be administered with other antihypertensive agents 


• It can be taken any time of the day 


• Do not break the tablet in half 


• Correct if known volume depletion prior to starting the medicine

How to store Irbesartan/hydrochlorothiazide:

• Keep this medicine out of the sight and reach of children.


• Store at Room Temperature [77°F (25°C)]. 


• Do not store above 30°